Mitochondrial DNA Deletions in Human Skin Reflect Photo-Rather than Chronologic Aging
نویسندگان
چکیده
منابع مشابه
Somatic mitochondrial DNA deletions accumulate to high levels in aging human extraocular muscles.
PURPOSE. Mitochondrial function and the presence of somatic mitochondrial DNA (mtDNA) defects were investigated in extraocular muscles (EOMs) collected from individuals covering a wide age range, to document the changes seen with normal aging. METHODS. Cytochrome c oxidase (COX) and succinate dehydrogenase (SDH) histochemistry was performed on 46 EOM samples to determine the level of COX defici...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1998
ISSN: 0022-202X
DOI: 10.1046/j.1523-1747.1998.00337.x